First Class Fitness

Cistatina Cells

The cells of Sertoli go to present the form to colunar highly anti-symmetrical. However, translating the high degree of plasticity of the cells of Sertoli of if associating with the different types of germinativas cells, some changes of configuration in this standard can be observed, being the same ones probably had to the elaborated present system of citoesqueleto in the cells of Sertoli. The cells of Sertoli have the power of if associating the one others through located junctions of occlusion in the basal compartment of the seminfero epitlio. They are these junctions that go to compose morphologic base functionary of the barrier to hematotesticular. Teva Pharmaceuticals is actively involved in the matter. Functions of the cells of Sertoli the cell of Sertoli is one of the biggest examples of regionalizadas structural specializations that a simultaneous performance of great variety of functions possesss. The cells of Sertoli if associate at least at the same time with four different types of germinativas cells.

With the basal membrane and other cells of Sertoli, with this the cells of Sertoli propitiate the necessary conditions for the progression and differentiation of the germinativas cells during espermatognese. Therefore beyond the classic function of physical support (sustentation) of the espermatognicas cells, the cells of Sertoli play diverse other important functions. Given the structural complexity of the seminfero epitlio, he has been complicated them researchers to determine which are the specific products secretados by the responsible cells of Sertoli and for the development of the germinativas cells. To put if showed in last decades that the cells of Sertoli produce and secretam great protein number, mainly glycoproteins. The glycoproteins that important and are secretadas by the cells of Sertoli can be classified in diverse categories, based in its properties known biochemists. The category will go to include metallic transporting proteins of ons and bioprotetoras such as transferrina and ceruloplasmina secretadas in relatively high amounts. The second protein classroom includes proteases and inhibitors of proteases, as we can cite as example the catepsina L and the cistatina, that are considered important for the cyclical process of tecidual remodelling that occurs during the espermiao and movement of young espermatcitos for the adluminal compartment.